Comparison of biometrical models for joint linkage association mapping

A Review on Joint Models in Biometrical Research

In some fields of biometrical research joint modelling of longitudinal measures and event time data has become very popular. This article reviews the work in that area of recent fruitful research by classifying approaches on joint models in three categories: approaches with focus on serial trends, approaches with focus on event time data and approaches with equal focus on both outcomes. Typical...

linkage disequilibrium and association mapping

Joint linkage and linkage disequilibrium mapping in natural populations.

A new strategy for studying the genome structure and organization of natural populations is proposed on the basis of a combined analysis of linkage and linkage disequilibrium using known polymorphic markers. This strategy exploits a random sample drawn from a panmictic natural population and the open-pollinated progeny of the sample. It is established on the principle of gene transmission from ...

Shared Components Models in Joint Disease Mapping: A Comparison

Two models for jointly analysing the spatial variation of incidences of three (or more) diseases, with common and uncommon risk factors, are compared via a simulation experiment. In both models, the linear predictor can be decomposed into shared and disease-specific spatial variability components (named shared clustering and specific clustering respectively). The two models are the shared model...

Joint tests of linkage and association for quantitative traits.

In this paper we describe various study designs and analytic techniques for testing the joint hypothesis that a genetic marker is both linked to and associated with a quantitative phenotype. Issues of power and sampling are addressed. The distinction between methods that explicitly examine association and those that infer association by examining the distribution of allelic transmissions from a...